Myles Garrett tries to help the Browns NFL odds in Week 6.


The Kansas City Chiefs lost for the first time last week, while the San Francisco 49ers were thrust into the NFL betting spotlight after moving to 4-0. Sunday’s loss to the Indianapolis Colts may give bettors pause before taking the Chiefs in future weeks, but the 49ers continue to reward fans who bet on the NFL after moving to 4-0 SU and 3-1 ATS. They’ll have a golden opportunity to force discussion about their status as a Super Bowl contender when they face the Los Angeles Rams this Sunday.

2019 NFL Week 6 Best Odds and Matchups

San Francisco 49ers at Los Angeles Rams (Sunday, 4:05 PM ET)

In what is turning out to be the most important game of the week, the 4-0 49ers will be up against the 3-2 Rams. LA has long been thought of as the top team in the division, but a 49ers’ victory could signal a changing of the guard in the NFC West. It’ll be a tight one to cover for the Rams, who are 3.5-point favourites, with a total of 51. 

New York Giants at New England Patriots (Thursday, 8:20 PM ET)

The 2-3 (SU and ATS) New York Giants came back to earth last week with a 28-10 loss to the Minnesota Vikings. While no one is expecting the Giants to beat the Patriots (5-0 SU, 3-2 ATS), it’s a big 17.5-point spread that’ll be the real challenge on the NFL betting odds. A total of 41 points should be manageable for two teams that have averaged 50.6 points per game collectively so far this season.  

Carolina Panthers at Tampa Bay Buccaneers (Sunday, 9:30 AM ET)

Since Cam Newton’s injury in Week 2, RB Christian McCaffrey has taken over the Panthers’ (3-2 SU and ATS) offense and it’s paying dividends. He accumulated 422 of his 587 rushing yards on 74 carries over the last three weeks. The Bucs do have the second-best run D in the NFL (69.8 yards per game), so it’ll be strength against strength in this one. Despite that, Carolina are 2-point “road favourites” in London.

New Orleans Saints at Jacksonville Jaguars (Sunday, 1 PM ET)

While it was the Alvin Kamara show early after Drew Brees’ injury, backup Teddy Bridgewater has gained the confidence of the New Orleans Saints’ (4-1 SU, 3-2 ATS) coaching staff. The odds on NFL Sunday have New Orleans as 1-point road dogs against the 2-3 Jags (3-2 ATS) with a total of 44.5, so this may be a game to jump on. 

Seattle Seahawks at Cleveland Browns (Sunday, 1 PM ET)

Early MVP candidate Russel Wilson has led his Seahawks to an impressive 4-1 SU, 2-3 ATS record to open the season. They’ll be up against the unpredictable Cleveland Browns (2-3 SU and ATS) in Week 6. Because no one knows which Browns team we’ll see on Sunday, the ‘Hawks are laying a slim 2 points on the NFL odds board.

*Odds as of  October 10, 2019