The Dallas Cowboys, Green Bay Packers, Los Angeles Rams and Buffalo Bills all saw their perfect records slip away in Week 4, and they’ll each press the reset button in preparation for Week 5. But one of these clubs will be faced with two straight losses after Sunday, as Dak and the Boys face Rodgers and the Packers on Sunday afternoon. Read on as we preview this game and nine other crucial matchups for NFL Week 5.

2019 NFL Week 5 Best Odds and Matchups

Green Bay Packers at Dallas Cowboys (Sunday, 4:25 PM ET)

If you like to bet on the NFL, this is the game for you. Both clubs will be focused on avoiding losing two straight games and tarnishing a great 3-0 start to the season. This could easily be a preview of the NFC Championship game, so it’ll be interesting to see if Dallas can cover the 3.5-point spread as home favourites.

Los Angeles Rams at Seattle Seahawks (Thursday, 8:20 PM ET)

The Rams (3-1 SU and ATS) will have little time to lick their wounds after a messy 55-40 loss to the Tampa Bay Buccaneers in Week 4. Their D surrendered 464 total yards, and Jared Goff threw three interceptions and lost a fumble. They’ll need to be sharper against a Seahawks team that’s 3-1 SU and 2-2 ATS. With home field advantage, the ‘Hawks are 1.5-point favourites on the NFL betting odds board.

Baltimore Ravens at Pittsburgh Steelers (Sunday, 1 PM ET)

A classic showdown between two AFC North teams will have a different flavour than typical. Instead of smash-mouth football, we’ll see the big-play Ravens’ offense up against a Steelers team that’s searching for its identity after losing Ben Roethlisberger for the season. The 2-2 SU, 1-3 ATS Ravens are a bit of a mystery through four weeks of play, but the odds on NFL Sunday still have them laying 3.5 points as road favourites with a 44.5-point total.

Buffalo Bills at Tennessee Titans (Sunday, 1 PM ET)

The Bills (3-1 SU and ATS) performed admirably against the Patriots last week, but ultimately fell to the defending champs 16-10. They payed dearly with the loss of starting QB Josh Allen, who is in concussion protocol after taking a hit to the head. Backup Matt Barkley will get the nod against the 2-2 SU and ATS Titans. Both of these teams have top-five defenses, so the NFL betting total has been set at a week-low 38.5. 

Chicago Bears at Oakland Raiders (Sunday, 1 PM ET)

The Bears will also be without their starting quarterback in Week 5 after Mitch Trubisky separated his shoulder and suffered a labrum tear. Surprisingly, the QB isn’t expected to miss significant time, but won’t be playing against Oakland in London. Both clubs are 2-2 ATS, and since neither team benefits from home field advantage, the Bears are favoured by five points with the total set at 40.5 on the NFL lines.

Jacksonville Jaguars at Carolina Panthers (Sunday 1 PM ET)

Week 5’s matchup between the Jags and Panthers is a battle between backup quarterbacks turned starters. Both Gardner Minshew and Kyle Allen are getting the job done for their respective clubs, leading their teams to 2-2 SU records. Both defences have been middle-of-the-road so far this season, but Carolina is laying 3.5 points at home where they’re 0-2 so far. 

New England Patriots at Washington Redskins (Sunday, 1 PM ET)

In the biggest spread of the week, the visiting Patriots will test their perfect (SU) record against the winless (SU) ‘Skins. The Patriots (2-2 ATS) have had trouble covering so far this year, but their fifth-ranked offense may be able to cover the 16-point spread against Washington’s second-worst-ranked D.

Tampa Bay Buccaneers at New Orleans Saints (Sunday, 1 PM ET)

The Bucs showed how good they can be against the Rams last week, and they’ll hope to continue that success against yet another Super Bowl hopeful by upsetting the homefield Saints on the NFL odds. Both teams carry a 2-2 ATS record thus far, but the Saints have had a lot more adversity as they struggle to get wins without Drew Brees at the helm. Despite that, they’re 3-point home favourites with a total of 47.

Indianapolis Colts at Kansas City Chiefs (Sunday, 8:20 PM ET)

The week’s highest total (56.5) goes to none other than the Kansas City Chiefs (4-0 SU, 3-1 ATS), who are tied for the most points scored per game in the NFL (33.8). They’ll welcome the Colts (2-2 SU, 2-1-1 ATS), who are coming off of a disappointing loss to the Raiders last week. The Chiefs have a hefty 11-point spread to cover in this one.

Cleveland Browns at San Francisco 49ers (Monday, 8:15 PM ET)

We’re all curious to see which Cleveland Browns (2-2 SU and ATS) team will take the field on Monday Night Football against the 49ers (3-0 SU, 2-1 ATS). The Browns have shown flashes of brilliance and disappointment all in just four weeks. The 49ers, meanwhile, are coming off of a bye, so they’ll be fresh and ready to extend their perfect record; as a result, they’re 3.5-point home favourites. 

*Odds as of  October 3, 2019