An NFC South matchup in Atlanta is on the Thanksgiving menu when the Saints take on the Falcons.

NFL Week 13: Top Offense vs. No. 2 Defense in Ravens-49ers Matchup

Thanksgiving means more than just turkey and good cheer south of the border; it also means a full docket for football and more opportunities to bet on the NFL than you could hope for. Leading the way is a Sunday afternoon game between division leaders and potential Super Bowl contenders, as the San Francisco 49ers will take on the top offense in the NFL when they visit Lamar Jackson and the Baltimore Ravens. This matchup between powerhouses takes the cake on the NFL odds board, but it isn’t the only game that deserves your NFL betting attention.

NFL Week 13 Best Odds and Matchups

San Francisco 49ers at Baltimore Ravens (Sunday, 1 PM ET)

The odds on NFL Sunday will be put to the test when two of the best teams in the NFL clash on Sunday. It’ll be the Ravens’ (9-2 SU, 6-5 ATS) offense versus the 49ers’ (10-1 SU, 6-4-1 ATS) defense, and the Ravens are laying six points as home favourites with a total of 47.

Buffalo Bills at Dallas Cowboys (Thursday, 4:30 PM ET)

The Cowboys were just one score away from upsetting the league-leading Patriots in Week 12, but dropped to 6-5 (7-4 ATS) on the season with a 13-9 loss. It’ll be another tough task at home when they take on the Bills (8-3 SU, 7-3-1 ATS), who’ve won two straight. The ‘Boys are favoured by 7 points, and the total is 46.5..

New Orleans Saints at Atlanta Falcons (Thursday, 8:20 PM ET)

An NFC South matchup in Atlanta is on the Thanksgiving menu when the Saints (9-2 SU, 7-4 ATS) take on the Falcons (3-8 SU, 4-7 ATS). While these teams are at opposite ends of the division, the Saints are thin 7-point favourites to beat the Falcons after being upset by them in Week 10. The 49-point total should be well within reach.

Tennessee Titans at Indianapolis Colts (Sunday, 1 PM ET)

The Tennessee Titans (6-5 SU, 5-5-1 ATS) are making a push in the AFC South, and they’ll have a chance to leapfrog the Colts (6-5 SU, 6-4-1 ATS) when the division rivals meet on Sunday afternoon. The 2.5-point spread favours the Colts, but don’t be surprised if the Titans make it three wins in a row.

Cleveland Browns at Pittsburgh Steelers (Sunday 1 PM ET)

Another divisional matchup is set for Sunday when the Browns (5-6 SU, 4-6-1 ATS) head to Steel City to take on the Steelers (6-5 SU, 7-4 ATS). The Browns are coming off of a third-straight win and are laying 2.5 points as road favourites. The total is a miniscule 40 points.

Green Bay Packers at New York Giants (Sunday, 1 PM ET)

The Packers (8-3 SU, 7-4 ATS) were absolutely thumped in Week 12 by the 49ers and now know they’ll need to step up their game if they hope to be Super Bowl contenders. While the Giants (2-9 SU, 4-7 ATS) won’t be the team to prove the Packers’ prowess, a win will help Green Bay get back on track. Not surprisingly, the Pack are 7-point road favourites in this one.

Los Angeles Rams at Arizona Cardinals (Sunday, 4:05 PM ET)

The Rams’ (6-5 SU, 7-4 ATS) playoff chances are slipping away by the week, so it’ll be critical for them to make a statement against the Cardinals (3-7-1 SU, 7-3-1 ATS). Despite the clear talent discrepancy between these clubs, LA is laying just three points on the NFL odds board. The 47.5-point total is a big one for two teams that average 45.1 points collectively.

Oakland Raiders at Kansas City Chiefs (Sunday, 4:25 PM ET)

Despite a 108-point differential between the Oakland Raiders (6-5 SU, ATS) and Kansas City Chiefs (7-4 SU, 6-5 ATS), Oakland will have a chance to tie the Chiefs atop the AFC West with an upset. The NFL lines list Mahomes and the Chiefs as 10-point favourites; can they cover?

New England Patriots at Houston Texans (Sunday, 8:20 PM ET)

Tom Brady and the Patriots (10-1 SU, 7-4 ATS) continue to march along, and the next opponents in their line of fire are the Texans (7-4 SU, 5-6 ATS). With New England’s focus on defense, they’re just 3.5-point road favourites.

Minnesota Vikings at Seattle Seahawks (Monday, 8:15 PM ET)

Perhaps one of the most intriguing matchups of the week is between the Vikings (8-3 SU, 6-5 ATS) and the Seahawks (9-2 SU, 6-5 ATS). With a victory, both teams will have an opportunity to tie for first in their divisions. The 3-point spread is razor thin in favour of the Seahawks, but this one is anyone’s guess.