NFL Betting: Week 6 Top Matchups   

The Arizona Cardinals continued to march along in Week 5 of the NFL regular season and are the only remaining undefeated team in the league. As a result, their NFL betting odds to win the Super Bowl have improved to +1200. In the NFC East, the Dallas Cowboys appear to be the real deal at 4-1, while the Green Bay Packers have won four straight after dropping their Week 1 matchup and now lead the NFC North. 

On the opposite side of the coin, the Kansas City Chiefs are now 2-3 after a Week 5 loss to Josh Allen and the Buffalo Bills and are now last in the AFC West. This Sunday should prove interesting for these clubs. 


Tampa Bay Buccaneers (-7) @ Philadelphia Eagles

Lincoln Financial Field, Philadelphia, Pennsylvania 

Thursday, October 14, 8:20 PM ET  

The Buccaneers are coming off of a dominant 45-17 victory over the Miami Dolphins. QB Tom Brady had a week for the ages, racking up five touchdowns and 411 passing yards. With that performance, Brady now leads the NFL with 1,767 passing yards and is second in total touchdowns (15). Philly won an important game against the Panthers to improve their record to 2-3, which is a tie for second in the NFC East with Washington. Given the Eagles’ dominance defending the pass (third in the NFL), Philly’s secondary could prove to be a game changer and give them a chance to cover, or win.


Cincinnati Bengals (-3.5) @ Detroit Lions 

Ford Field, Detroit, Michigan 

Sunday, October 17, 1:00 PM ET 

The Lions can’t seem to catch a break this season. They’re now 0-5 SU, but a surprising 3-2 ATS. They’re certainly better than their 0-5 record would suggest and have lost in spectacular fashion in two of the last three weeks, as opposing kickers sealed their fate in the final seconds of the games.  

Cincinnati enters Week 6 3-2 SU (2-3 ATS), but each of their wins has come against sub-500 clubs. While they held their own against the Packers, two missed field goals were their undoing. You can bet the Lions will come out hard knowing the Bengals’ vulnerability, which is why Cincinnati is favoured by just three points. 


Kansas City Chiefs (-7) @ Washington Football Team 

FedExField, Landover, Maryland 

Sunday, October 17, 1:00 PM ET 

The Kansas City Chiefs are reeling. At 2-3 SU and 1-4 ATS, the Chiefs can’t stop opposing offenses. They give up the most points per game in the entire NFL at 32.6 PPG, and things aren’t going to get easier for them after CB Charvarius Ward and DE Chris Jones were both injured in their 38-20 loss to the Buffalo Bills and have been ruled out for Sunday’s matchup at press.  

For Washington, they’re hanging on in the NFL East with a 2-3 SU and 1-4 ATS record on the season. While there’s no question that the Chiefs are a superior football team, Washington may be able to take advantage of KC’s porous defense and injury troubles and improve their league-worst ATS record. 


Arizona Cardinals @ Cleveland Browns (-3.5) 

First Energy Stadium, Cleveland, Ohio 

Sunday, October 17, 4:05 PM ET 

Cleveland fans may be getting fed up with the 3-2 (SU and ATS) Browns after their implosion against the Los Angeles Chargers on Sunday, but there’s still hope that they’ll serve the Cardinals their first regular season loss. They’ll be laying 2.5 points to the unbeaten Arizona Cardinals (4-1 ATS), with a total of 50.5. There’s speculation over whether or not the Cards will be able to continue their undefeated streak with injuries to C Rodney Hudson, CB Marco Wilson and CB Byron Murphy Jr. Look for Mayfield to exploit the Cardinals’ second-string cornerbacks and hand Arizona their first loss of the season. 


Dallas Cowboys (-3.5) @ New England Patriots 

Gillette Stadium, Foxborough, Massachusetts 

Sunday, October 17, 4:25 PM ET 

The Dallas Cowboys continue to be a sure thing on the odds board, sporting a 5-0 ATS record (4-1 SU). They flexed their muscles in a 44-20 beatdown of the New York Giants in Week 5, with RBs Ezekiel Elliott and Tony Pollard leading the way with 185 total rushing yards. The Cowboys’ ground game now ranks second in the NFL, averaging 172.8 yards per game. New England’s defense is in the middle of the pack; combined with their offense, which averages just 19.2 points per game, the Patriots could contribute to the Under (-110) paying out on the 49.5-point total.  

Seattle Seahawks @ Pittsburgh Steelers (-5) 

Heinz Field, Pittsburgh, Pennsylvania 

Sunday, October 17, 8:20 PM ET 

The Steelers won a critical game in Week 5 versus the Denver Broncos to keep within striking distance of the rest of the AFC North. It’s not looking good for the Steelers, however, after WR JuJu Smith-Schuster was lost for the season with a shoulder injury. But playing at home versus the Seahawks, who are coming off of a loss on Thursday to the Rams, could pave the way for a Steelers win.  

Buffalo Bills (-6) @ Tennessee Titans 

Nissan Stadium, Nashville, Tennessee  

Monday, October 18, 8:15 PM ET 

The Week 6 edition of Monday Night Football will see a clash between two AFC division leaders when the Buffalo Bills (4-1 SU, ATS) head to Nashville to take on the Tennessee Titans (3-2 SU, ATS). The Bills are riding high after pulling off an upset against the Kansas City Chiefs to enter a three-way tie for first in the AFC. With the top offense (34.4) and defense (12.8 PPG) in the NFL, they’ve pushed their way to second on the Super Bowl futures market (+600). Their third-ranked rush defense will be tested when they go up against the league’s leading rusher, Derrick Henry, who has scored the lion’s share of touchdowns (7) for the Tennessee Titans.